abstract：:Buprenorphine is a semi-synthetic opioid derived from thebaine. The transdermal formulation of buprenorphine has been available in Belgium for 3 years, during which time the Pain Clinic of the St Elisabeth of Verviers Hospital has gained experience in the use of transdermal buprenorphine for the treatment of moderate-...

journal_title：International journal of clinical practice

authors： Louis F

更新日期：2006-10-01 00:00:00

abstract：:Hypogonadism may play a significant role in the pathophysiology of erectile dysfunction (ED). A threshold level of testosterone may be necessary for normal erectile function. Testosterone replacement therapy is indicated in hypogonadal patients and is beneficial in patients with ED and hypogonadism. Monotherapy with t...

journal_title：International journal of clinical practice

authors： Shabsigh R,Rajfer J,Aversa A,Traish AM,Yassin A,Kalinchenko SY,Buvat J

更新日期：2006-09-01 00:00:00

abstract：:The misery of living with atopic eczema (syn. dermatitis, AD) cannot be overstated for it may have a profoundly negative effect on the health-related quality of life (HRQoL) of children and their family unit in many cases. As it is one of the commonest chronic relapsing childhood dermatosis (UK lifetime prevalence 16-...

journal_title：International journal of clinical practice

authors： Lewis-Jones S

更新日期：2006-08-01 00:00:00

abstract：:A randomised, double-blind, parallel, placebo-controlled, 12-week study was carried out to evaluate the efficacy and safety of 20-mg tadalafil taken 'as needed' in a population of men with erectile dysfunction (ED) from Egypt and Turkey. One hundred and thirty-two patients were randomised in this study. Tadalafil was ...

journal_title：International journal of clinical practice

authors： Saylan M,Khalaf I,Kadioglu A,Shoair KZ,Beheiry A,Wang WC,Kopernicky V,Esen A

更新日期：2006-07-01 00:00:00

abstract：:This prospective study describes and evaluates the efficacy of an integrated care pathway for the management of the critically ischaemic diabetic foot patients by a multidisciplinary team. A weekly joint diabetes/vascular/podiatry ward round and outpatient clinic was established where patients were assessed within 7 d...

journal_title：International journal of clinical practice

authors： El Sakka K,Fassiadis N,Gambhir RP,Halawa M,Zayed H,Doxford M,Greensitt C,Edmonds M,Rashid H

更新日期：2006-06-01 00:00:00

abstract：:Gastrointestinal tract (GIT) foreign bodies represent a significant clinical problem in the Emergency Department, causing a high degree of financial burden, morbidity and mortality. A large variety of foreign bodies are accidentally ingested or inserted into the GIT in different age groups. This a retrospective review...

journal_title：International journal of clinical practice

authors： Ayantunde AA,Oke T

更新日期：2006-06-01 00:00:00

abstract：:This trial assessed whether a simple clinical tool can be used to stratify patients with diabetes, according to risk of developing foot ulceration. This was a prospective, observational follow-up study of 3526 patients with diabetes (91% type 2 diabetes) attending for routine diabetes care. Mean age was 64.7 (range 15...

journal_title：International journal of clinical practice

authors： Leese GP,Reid F,Green V,McAlpine R,Cunningham S,Emslie-Smith AM,Morris AD,McMurray B,Connacher AC

更新日期：2006-05-01 00:00:00

abstract：:Over the past years, there has been an explosive increase in the prevalence of type 2 diabetes (T2DM) and this is expected to continue, entailing associated morbidity and mortality. An increasing number of studies explore the different ways T2DM could be prevented. On-going lifestyle modifications need to be addressed...

journal_title：International journal of clinical practice

authors： Gruber A,Nasser K,Smith R,Sharma JC,Thomson GA

更新日期：2006-05-01 00:00:00

abstract：:Obesity is the major risk factor for the development of hypertension. This association accentuates the risk of cardiovascular disease, as it is frequently accompanied by the components of the metabolic syndrome. This randomised open parallel study evaluated the chronic effects of moxonidine--a selective imidazoline re...

journal_title：International journal of clinical practice

authors： Sanjuliani AF,de Abreu VG,Francischetti EA

更新日期：2006-05-01 00:00:00

abstract：:This double-blind, randomised, controlled study compared the efficacy of candesartan cilexetil 8 mg (n = 87) and losartan 50 mg (n = 89), once daily for 6 weeks, relative to placebo (n = 80) in patients with mild-to-moderate essential hypertension (diastolic blood pressure (DBP): 95-115 mmHg). Ambulatory BP measuremen...

journal_title：International journal of clinical practice

authors： Baguet JP,Nisse-Durgeat S,Mouret S,Asmar R,Mallion JM

更新日期：2006-04-01 00:00:00

abstract：:Monomeric prolactin (PRL) of molecular weight 23 kDa constitutes up to 95% of adult serum PRL. Macroprolactin is a large antigen-antibody complex of molecular weight greater than 100 kDa and constitutes less than 1% of circulating PRL. Thus, in most cases, hyperprolactinaemia is usually a result of high levels of mono...

journal_title：International journal of clinical practice

authors： Sadideen H,Swaminathan R

更新日期：2006-04-01 00:00:00

abstract：:Despite efforts to diagnose and treat hypertension effectively, the goal of lowering blood pressure (BP) levels is rarely achieved, as treatment is often initiated with a single antihypertensive agent. The aim of this study was to assess the safety and efficacy of a first-line fixed-dose combination treatment compared...

journal_title：International journal of clinical practice

authors： Scholze J,Bida M,Hansen A,Juncken D,Rangoonwala B,Ritz A,Schnitker J,Dörffel Y

更新日期：2006-03-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most lethal of the common solid malignancies. It is predominantly a disease of the elderly with the median age at diagnosis 68 years. Unfortunately, the majority of patients present with advanced disease whereby palliation is the primary aim of treatment. The elderly have a lo...

journal_title：International journal of clinical practice

authors： Cheong KA,Chrystal K,Harper PG

更新日期：2006-03-01 00:00:00

abstract：:The current study compared the effectiveness of the graduated tuning fork (128 Hz) and the neurothesiometer in assessing vibration sensation perception in patients presenting with type II diabetes mellitus. A quota sample of patients (n = 21; age range 43-73 years) were assessed using the neurothesiometer and tuning f...

journal_title：International journal of clinical practice

authors： O'Neill J,McCann SM,Lagan KM

更新日期：2006-02-01 00:00:00

abstract：:A press through package (PTP) is commonly used as a package for drugs and also being seen increasingly in cases of foreign body in the digestive tract. We presented three cases of inadvertent PTP ingestion with a variety of clinical presentations. Although commonly considered to be small and soft to cause bowel damage...

journal_title：International journal of clinical practice

authors： Hou SK,Chern CH,How CK,Wang LM,Huang CI,Lee CH

更新日期：2006-02-01 00:00:00

abstract：:The following article reviews treatment for acne vulgaris. Selection of therapy should be based on clinical appearance taking into account lesion type and severity, as well as identification of acne scarring and the psychosocial disability caused by the disease. ...

journal_title：International journal of clinical practice

authors： Layton AM

更新日期：2006-01-01 00:00:00

abstract：:This double-blind, randomised placebo-controlled, multicentre study evaluated the efficacy, tolerability and safety of 12 weeks' treatment with controlled release darifenacin 15 mg once daily (qd), in 445 patients with overactive bladder (OAB). The primary endpoint was warning time (time from first sensation of urgenc...

journal_title：International journal of clinical practice

authors： Zinner N,Susset J,Gittelman M,Arguinzoniz M,Rekeda L,Haab F

更新日期：2006-01-01 00:00:00

abstract：:This study was to evaluate the efficacy and safety of ibutilide and propafenone given intravenously in converting recent onset atrial fibrillation (AF). Eighty-two consecutive patients with AF (onset in 2 h to 90 days) were randomly assigned to receive two 10-min infusions, 10 min apart, of either ibutilide (1 mg) or ...

journal_title：International journal of clinical practice

authors： Zhang N,Guo JH,Zhang HCh,Li XB,Zhang P,Xn Y

更新日期：2005-12-01 00:00:00

abstract：:Ezetimibe/simvastatin (INEGY), a dual inhibitor of both cholesterol production and absorption, is a new approach to the management of hyperlipidaemia. Recent studies have shown that it produces greater reductions in low-density lipoprotein (LDL) cholesterol than the single inhibition of statin therapy, enabling many m...

journal_title：International journal of clinical practice

authors： Kastelein JJ,Sankatsing RR

更新日期：2005-12-01 00:00:00

abstract：:Although uric acid (UA) is considered as an antioxidant, the relationship between serum UA levels and cardiovascular diseases is not clear yet. Higher brachial artery resting diameter (BD), impaired brachial artery flow-mediated dilatation (FMD), increased carotid intima-media thickness (IMT), decreased aortic distens...

journal_title：International journal of clinical practice

authors： Erdogan D,Gullu H,Caliskan M,Yildirim E,Bilgi M,Ulus T,Sezgin N,Muderrisoglu H

更新日期：2005-11-01 00:00:00

abstract：:Thyroid cancer is uncommon with an estimated lifetime risk of 0.8% for women and 0.3% for men. The incidence appears to be increasing by 4% per year and is currently the eighth commonest cancer in women. Managing thyroid cancer is challenging, as no prospective randomised trials exist. Most of the information is deriv...

journal_title：International journal of clinical practice

authors： Nix P,Nicolaides A,Coatesworth AP

更新日期：2005-11-01 00:00:00

abstract：:We assessed the cost-effectiveness of acarbose in the management of patients with impaired glucose tolerance (IGT) in Sweden, based on progression to type 2 diabetes (T2D) and cardiovascular (CV) events reported in the STOP-NIDDM trial population, including high-risk subgroups. The cost per patient free from T2D was S...

journal_title：International journal of clinical practice

authors： Quilici S,Chancellor J,Maclaine G,McGuire A,Andersson D,Chiasson JL

更新日期：2005-10-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with gastrointestinal adverse effects, ranging from dyspepsia and peptic ulcer disease to more serious complications such as haemorrhage or perforation. NSAID-induced gastrointestinal toxicity is a significant medical problem worldwide. Misoprostol is effec...

journal_title：International journal of clinical practice

authors： Singh G,Triadafilopoulos G

更新日期：2005-10-01 00:00:00

abstract：:The aim of this study was to identify the aerobic and the anaerobic microorganisms which can be related to duct ectasia. The patients were divided into two groups. Group 1 comprised 100 patients with coloured nipple discharge (duct ectasia group), and Group 2 (the control group) was composed of 50 patients without nip...

journal_title：International journal of clinical practice

authors： Rahal RM,Júnior RF,Reis C,Pimenta FC,Netto JC,Paulinelli RR

更新日期：2005-09-01 00:00:00

abstract：:Carcinoma erysipelatoides, also known as inflammatory metastatic carcinoma, is a rare form of cutaneous metastasis from a malignancy. The characteristic histopathological finding is metastatic tumour cells inside the dermal lymphatic ducts. It is frequently observed in patients with breast carcinoma as well as adenoca...

journal_title：International journal of clinical practice

authors： Yu KJ,Lee HE,Ho HC,Lee JC,Chang JW,Hong HS,Yang CH

更新日期：2005-09-01 00:00:00

abstract：:Summary The objective of this study was to determine whether Ramadan is changing frequencies and demographics of visits due to certain diseases. Data obtained from the charts of the adult patients admitted into the emergency department (ED) due to 10 predetermined entities between 2000 and 2004 were analysed. Demograp...

journal_title：International journal of clinical practice

authors： Topacoglu H,Karcioglu O,Yuruktumen A,Kiran S,Cimrin AH,Ozucelik DN,Sarikaya S,Soysal S,Turpcu U,Bozkurt S

更新日期：2005-08-01 00:00:00

abstract：:Fever of unknown origin (FUO) is defined as the body temperature higher than 38.3 degrees C on several occasions and lasting longer than 3 weeks, with the aetiology remaining uncertain after 1 week of investigation. In this study, we reviewed 57 patients with FUO hospitalised in our inpatient department between 1998 a...

journal_title：International journal of clinical practice

authors： Erten N,Saka B,Ozturk G,Karan MA,Tascioglu C,Dilmener M,Kaysi A

更新日期：2005-08-01 00:00:00

abstract：:We performed the present study to compare patients with migraine and tension-type headache (TTH) in their behaviour during the attacks and the manoeuvres to relieve the pain. One hundred thirty consecutive patients with either migraine (n = 75) or TTH (n = 55) were questioned (including the use of a checklist) concern...

journal_title：International journal of clinical practice

authors： Bag B,Karabulut N

更新日期：2005-07-01 00:00:00

abstract：:It is important for primary care physicians to recognise rheumatoid arthritis and systemic lupus erythematosus patients as high-risk groups for atherosclerosis, requiring aggressive risk-factor modification. Recent studies suggest that this increased risk is not explained by an excess of traditional risk factors, but ...

journal_title：International journal of clinical practice

authors： Farzaneh-Far A,Roman MJ

更新日期：2005-07-01 00:00:00

abstract：:We sought to clarify whether impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both (IFG/IGT) represent the most severe impairment in insulin resistance (IR) and insulin secretion. Among the 159 Chinese subjects, 21 were diagnosed as having IFG, 103 as having IGT and 35 as having both. IR and beta-ce...

journal_title：International journal of clinical practice

authors： Hsieh CH,Kuo SW,Hung YJ,Shen DC,Ho CT,Lian WC,Lee CH,Fan SC,Pei D

更新日期：2005-06-01 00:00:00

abstract：:Gastric acid is pathogenic in many gastrointestinal disorders, such as gastroesophageal reflux disease and peptic ulcer disease. Proton pump inhibitors (PPIs) are the antisecretory drugs of choice for serious acid-related conditions. Ample recent data exist to explicate virtually every aspect of the clinical managemen...

journal_title：International journal of clinical practice

authors： Robinson M

更新日期：2005-06-01 00:00:00

abstract：:The efficacy of prophylactic carboxymethylcellulose (CMC) in reducing the time to reach full enteral feeds (FEFs) in neonates <32 weeks' gestation was studied in a clinical trial. When ready for feeds, enrolled neonates were allocated to either CMC (dose: CMC content of 12 mg oral erythromycin ethyl succinate syrup, 6...

journal_title：International journal of clinical practice

authors： Patole SK,Muller R

更新日期：2005-05-01 00:00:00

abstract：:A retrospective audit of (99m)Tc-HMPAO SPECT scans was undertaken to assess the utility of brain perfusion imaging in a cohort of young cognitively impaired patients in whom diagnostic uncertainty remained after standard clinical and neuropsychological assessment and structural brain imaging. SPECT scans were assessed...

journal_title：International journal of clinical practice

authors： Doran M,Vinjamuri S,Collins J,Parker D,Larner AJ

更新日期：2005-04-01 00:00:00

abstract：:Helicobacter pylori infection is one of the most prevalent infections in humans. The high prevalence and the association with peptic ulceration and gastric cancer require simple and non-invasive methods for the diagnosis of the infection. Detection of salivary anti-H. pylori IgG antibodies has advantages compared with...

journal_title：International journal of clinical practice

authors： Sönmezoglu M,Baysal B,Ergen A,Barut SG

更新日期：2005-04-01 00:00:00

abstract：:In this prospective qualitative study over 12 months, we evaluated the educational and clinical effectiveness of a new final year undergraduate programme in a London medical school (Guy's, King's and St Thomas'). A stratified sample of 17/360 final year students were interviewed four times, and the content was assesse...

journal_title：International journal of clinical practice

authors： Lempp H,Seabrook M,Cochrane M,Rees J

更新日期：2005-03-01 00:00:00

abstract：:We report a case of acute myocardial infarction in an HIV-infected patient without significant coronary artery disease (CAD) risk factors. The patient underwent rescue percutaneous transluminal coronary angioplasty (PTCA), with a successful outcome. We presume a possible pathogenetic role of anti-retroviral therapy an...

journal_title：International journal of clinical practice

authors： Saporito F,Micari A,Raffa S,Cerrito M,Micari G,Grassi R

更新日期：2005-03-01 00:00:00

abstract：:Prescriptions for short-acting beta(2)-agonists (SABAs) and oral corticosteroids recorded in a primary care database were used as markers of asthma control. Drug use in the 6 months before and after step-up in treatment from inhaled corticosteroids [ICs; total daily dosage of < or =1000 microg beclomethasone dipropion...

journal_title：International journal of clinical practice

authors： Angus R,Reagon R,Cheesbrough A

更新日期：2005-02-01 00:00:00

abstract：:Antihypertensive efficacy must be redefined beyond blood pressure (BP) lowering per se to include reducing the cardiovascular complications of hypertension. Treatment decisions should be based on results from large clinical trials with relevant clinical outcomes. Several recent morbidity and mortality trials with angi...

journal_title：International journal of clinical practice

authors： Conlin PR

更新日期：2005-02-01 00:00:00

abstract：:Cigarette smoking induces a significant oxidant effect related to variety of free radical-related diseases often affecting the upper respiratory tract, unless it is effectively compensated by the antioxidant barriers of the humans. In the present study, the evaluation of the antioxidant compensatory mechanisms, by est...

journal_title：International journal of clinical practice

authors： Charalabopoulos K,Assimakopoulos D,Karkabounas S,Danielidis V,Kiortsis D,Evangelou A

更新日期：2005-01-01 00:00:00

abstract：:This randomised, double-blind study compared the anti-hypertensive efficacy and tolerability of Candesartan cilexetil (CC 8-16 mg) and Amlodipine (AML 5-10 mg) on home blood pressure (HBP) measurements in mild-to-moderate hypertensive patients. After a 2-week wash-out, patients aged 18-74 years, with a sitting diastol...

journal_title：International journal of clinical practice

authors： Imbs JL,Nisse-Durgeat S,French Collaborative Candesartan Study Group.

更新日期：2005-01-01 00:00:00